A lot of noncoding RNA is really noncoding!
A lot of noncoding RNA is really noncoding! Transcriptomics is still booming -- there is so much awesome data being generated from all those cool instruments (I recently heard one of the newest ones can generate 3000GB of transcriptomic data per sample!) If youve been summarily browsing the biology literature, youve undoubtedly seen reclassification of some "non coding" genes as "coding", via these technologies. And there have definitely been several that have been validated at the protein level. However -- there have definitely been some that have been purported as "coding" via transcriptomics that do not make it to the protein level. Is it because mass spec based protein technologies just cant detect them? This new open paper at JPR takes an in-depth looks at some of these disagreements and concludes --- I feel bad for starting this post this way. It almost says -- here is the controversy and here is a response from some really smart Belgish people, but ...